Akili games and EndeavorRx: the video game treatment for ADHD

Akili Interactive says effective medicine for serious illness can also be fun and engaging, and it develops a class of digital medicines for people with cognitive impairment. Chief executive Eddie Martucci described the aim in 2020 as combining neuroscience with video game entertainment, with a treatment delivered through a game instead of a pill or syringe.

The company's patented technology is designed, according to Akili, to activate the brain networks responsible for cognitive function. Akili games are action games in which players move through settings such as a molten lava river or an icy winter wonderland and collect stars and points as they finish tasks. Akili treats the game as a delivery system for targeted algorithms. The company is based in Boston and says it chose action game experiences because they drive engagement and compliance.

The company's flagship product is EndeavorRx, an iPhone and iPad game for children with ADHD. In June 2020 the company announced that the U.S. Food and Drug Administration had permitted marketing. The EndeavorRx site calls it the first FDA-authorized video game for ADHD. The authorization rested on clinical study data, including a randomized controlled study published in The Lancet Digital Health.

At launch EndeavorRx was the centerpiece of the Endeavor Care Program, which pairs the game with Akili Care, a mobile tracking app with support services for caregivers. Families download the game from the App Store and need no extra equipment.

The EndeavorRx site, endeavorrx.com, loads in November 2026. The 2020 address my.akili.care/endeavor/ now forwards there. The page states that EndeavorRx is a prescription digital therapeutic that is not meant to replace ADHD medication, that federal law restricts sale to a prescription from a licensed health care provider, and that a free demo is available on the Apple App Store and Google Play. It lists a price of $99 per 30-day prescription.

The company site, akiliinteractive.com, is also live. It carries a 2022 copyright line and presents EndeavorRx for children alongside EndeavorOTC for adults. Neither page says who owns the company. Indication, age range and safety information are set out on the product's own site.